Zocor 20 mg Tablets

Simvastatin in Zocor reduces blood cholesterol levels, protecting blood vessels. The drug blocks the production of “bad” fats, reducing the risk of atherosclerosis and heart problems. It helps to maintain lipid balance, which is important for people with high triglycerides. It is suitable for those seeking to prevent complications from excess cholesterol.

Available

no RX

Dosage Package Per Item Per Pack Order
20 mg
30 Tabs $2.15 $64.50
60 Tabs $1.99 $119.40
90 Tabs $1.78 $160.46

Brand Name

Zocor enjoys a well-earned reputation as a top cholesterol-lowering medication, trusted by doctors, heart specialists, and pharmacists worldwide for its consistent effectiveness over many years. This brand has become a reliable choice in managing high lipid levels, helping patients in clinics and homes across the globe tackle cholesterol-related conditions.

Its long history of success makes Zocor a preferred option for healthcare providers everywhere. The drug stands out by offering dependable support for those aiming to protect their heart health.

International Nonproprietary Name

Simvastatin is the globally accepted generic name, carefully established by drug authorities to ensure that healthcare professionals can identify the active ingredient without confusion. This clear designation simplifies discussions among medical teams and sets the treatment apart from other cholesterol-lowering options available.

The name simvastatin reflects its primary role in reducing harmful lipids in the bloodstream. It provides a universal label that aids precise prescribing across diverse healthcare settings.

Form of Release

Zocor comes in the form of film-coated tablets designed for daily oral use, available in strengths of 10 milligrams, 20 milligrams, 40 milligrams, and 80 milligrams. Each dose is distinctly marked to avoid mix-ups, ensuring patients and providers can manage cholesterol treatment with ease.

These tablets are packaged in blister packs or bottles for convenience and protection. They offer a practical way to maintain consistent cholesterol control over time.

Composition

Simvastatin serves as the cornerstone of Zocor, acting as a statin carefully formulated to lower cholesterol levels with reliable results across every dose. The tablets combine this active ingredient with microcrystalline cellulose to keep their structure solid and magnesium stearate to assist during production.

Lactose monohydrate enhances stability within the formulation, while a hydroxypropyl cellulose coating provides a smooth finish. A small amount of ascorbic acid preserves their quality throughout their shelf life.

Pharmacologic Properties

Pharmacodynamics

Zocor targets an enzyme in your liver known as HMG-CoA reductase, which plays a key role in producing cholesterol within your body. By slowing this enzyme’s activity, the drug reduces how much cholesterol your liver makes, encouraging it to remove more low-density lipoprotein, often called LDL or "bad cholesterol," from your bloodstream.

This process can lower LDL levels by 20 to 50 percent, depending on your dose, your starting cholesterol, your genetics, or how much fatty food—like fried snacks or rich desserts—you eat regularly. Lowering LDL helps prevent fatty deposits from clogging your arteries, reducing risks of heart attacks, strokes, or leg pain from blocked blood flow—dangers that increase with smoking, high blood pressure, or a family history of cholesterol issues.

You’ll begin seeing these changes within 1 to 2 weeks, with the full effect kicking in after 4 to 6 weeks of daily use. Zocor also raises high-density lipoprotein, or HDL, the "good" cholesterol, by 5 to 15 percent and slightly lowers triglycerides, improving your overall blood balance.

Taking it at night aligns with your liver’s peak cholesterol production, maximizing its impact during those hours. Unlike treatments aimed at triglycerides or bile acids, Zocor focuses directly on cholesterol creation, and studies show a 40-milligram dose can cut heart event risks by 25 to 35 percent over 5 years—a vital benefit for anyone with high cholesterol or past heart trouble.

Pharmacokinetics

When you swallow a Zocor tablet, your stomach and intestines absorb about 60 to 85 percent of it, though your liver quickly processes most of the dose using cytochrome P450 3A4 enzymes. This leaves only around 5 percent active in your bloodstream, with peak levels appearing between 1 and 2 hours after taking it.

The drug spreads widely through your body, roughly 4 liters per kilogram, binding to proteins like albumin at 95 percent, which keeps just enough free to reach your liver and work its magic. Your liver converts simvastatin into active forms like simvastatin acid, along with some inactive leftovers, processing over 80 percent before it exits your system.

Most of it leaves through bile into your stool, about 60 percent, while a smaller portion exits via urine, around 13 percent. Its half-life lasts 2 to 3 hours, but active forms extend effects up to a day, fitting a once-nightly dose since your liver ramps up cholesterol production at night.

Liver issues like severe scarring can stretch this half-life, while kidney trouble has less impact because your liver handles most of the clearing—still, very weak kidneys with clearance under 30 milliliters per minute need extra care. Eating a fatty meal like steak or creamy pasta boosts absorption by 20-30 percent, so taking it after dinner can help, though keeping a steady daily time matters more, and blood tests aren’t usually needed since it clears predictably.

Indications Use

Conditions Diseases

Zocor manages high cholesterol when your LDL rises above 130 milligrams per deciliter, often due to diet, genetics, or eating fatty foods like cheeseburgers, helping prevent artery blockages that lead to heart attacks, strokes, or leg pain. These risks grow for adults over 40 with factors like smoking or high blood pressure pushing cholesterol trouble higher.

It also tackles mixed lipid issues where LDL is high alongside triglycerides over 150 milligrams per deciliter—common in diabetes or metabolic syndrome—reducing both to ease blood vessel strain while slightly boosting HDL for better balance. This supports patients managing these overlapping conditions.

For those who’ve had a heart attack, Zocor halves the chance of another over 5 years at 40 milligrams, keeping artery plaques stable in survivors with LDL above 100 milligrams per deciliter, often used with aspirin. It’s a key part of recovery for such patients.

In high-risk groups—like diabetics or smokers with LDL over 160 milligrams per deciliter—it slows plaque buildup to avoid chest pain or surgery needs, working best when paired with a diet keeping fats below 7 percent daily. This helps protect those most vulnerable to heart issues.

Contraindications

Conditions Prohibiting Use

Zocor isn’t safe if your liver faces active problems like hepatitis or severe scarring, as it’s processed there and could increase enzyme levels, potentially causing yellow skin or more serious trouble. Safer alternatives like ezetimibe step in until your liver recovers, with tests ensuring ALT stays under 40 units per liter before starting.

If you’ve had allergic reactions to simvastatin or statins before—such as rashes or breathing difficulty—you can’t use it since those could worsen into swelling or shock. Other treatments like bile binders take over, and your doctor reviews your allergy history first.

Pregnancy bans Zocor—it’s category X—because lowering cholesterol might harm a baby’s brain and spine development, raising defect risks by up to 20 percent, so stick to birth control or diet changes instead. Breastfeeding stops too, as simvastatin in milk could affect the baby, requiring safer options.

Strong drugs like ketoconazole that block its breakdown can spike levels 10 times, risking muscle damage—avoid them or switch to pravastatin, waiting 2 weeks after they’re done. Past severe muscle issues like rhabdomyolysis with pain and dark urine rule it out—diet or niacin fits better, with muscle tests ensuring creatine kinase stays under 150 units per liter.

Method Administration Dosage

Administration Guidelines

Z985ocor tablets are taken by mouth once a day, ideally at night after dinner since your liver produces the most cholesterol during those hours, giving the drug its best chance to work effectively. Swallow them whole with water to keep the dose steady—don’t crush or chew—and while a meal can slightly boost absorption, taking it on an empty stomach is fine too if that fits your routine better.

Stick to the same time each day, such as 7 PM, to maintain even levels in your blood, and avoid grapefruit juice because it can double the drug’s presence, stirring potential issues. Zocor comes only as tablets—no injectable versions exist—so keeping a regular schedule ensures steady cholesterol reduction.

Dosage Adults Children

Adults typically start Zocor at 20 to 40 milligrams each night—20 suits mild LDL cases between 130 and 160 milligrams per deciliter, while 40 tackles levels over 190, cutting LDL by 30 to 40 percent within 4 to 6 weeks based on blood tests aiming for under 100 milligrams per deciliter. After a heart attack, the target drops to 70, and you might increase to 80 milligrams after a month if needed, guided by how well it works and muscle comfort.

Kids aged 10 to 17 with family cholesterol problems, LDL over 160 milligrams per deciliter, begin at 10 milligrams nightly and may step up to 20 or 40 after 4 to 6 weeks if LDL stays above 130 despite diet efforts—the maximum is 40, checked every 3 months by specialists. Below age 10, it’s not used—diet takes priority instead.

Adults settle into a maintenance range of 10 to 80 milligrams—10 for slight elevations and 80 for post-heart attack or genetic cases, adjusted every 4 to 6 weeks with tests to keep LDL low and liver enzymes normal, under 40 units per liter. This ensures steady cholesterol control across different needs.

Dose Adjustment Specific Conditions

If your liver has moderate issues like some scarring, Zocor starts at 10 to 20 milligrams nightly because it stays in your system longer and could raise enzyme levels like ALT over 100 units per liter—begin with 10, test weekly, and move to 20 after 4 weeks if stable. Severe liver damage like cirrhosis avoids it entirely, favoring options like ezetimibe, with normal tests (ALT under 40 units per liter) required for higher doses.

Kidney problems with clearance between 10 and 30 milliliters per minute keep Zocor at 20 to 40 milligrams nightly since your liver does most of the clearing—start at 20, increase to 40 if LDL exceeds 100 after 6 weeks, and check monthly with blood work showing creatinine under 2 milligrams per deciliter, avoiding 80 unless kidneys improve.

Older adults begin at 20 milligrams because slower systems extend the half-life to 4 or 5 hours—they can rise to 40 if LDL remains high after 6 weeks, monitored every 6 weeks with muscle tests (creatine kinase under 150 units per liter) to catch soreness early, ensuring safety for frail bodies or drug combinations like amiodarone.

Side Effects

Possible Adverse Reactions

Muscle soreness, or myalgia, is Zocor’s most common side effect, affecting 5 to 10 percent with leg or back aches that typically emerge within 2 to 4 weeks at 40 to 80 milligrams—it’s often mild and fades naturally, though you might lower from 40 to 20 milligrams if muscle enzymes rise above 500 units per liter, checking weekly. Rarely, 0.1 percent face severe breakdown called rhabdomyolysis with intense pain and dark urine—stopping it quickly protects your kidneys.

Liver enzyme increases, where ALT or AST doubles, occur in 1 to 3 percent, mostly at 80 milligrams—tests every 3 months spot ALT over 120 units per liter, and cutting to 20 or 40 milligrams or pausing helps if it triples beyond 4 weeks. Gut upset like nausea, bloating, or constipation bothers 5 percent early, linked to higher doses—it settles with meals or within 2 to 3 weeks, and adding fiber aids if loose stools persist, prompting a doctor visit if it lingers.

Tiredness or headaches hit 5 to 7 percent initially, mild at 20 to 40 milligrams—they fade with water or in 1 to 2 weeks, and you can log it if sleep falters, ensuring Zocor’s benefits stay clear without much hassle.

Overdose

Symptoms Overdose

Taking too much Zocor, such as 400 to 800 milligrams, triggers muscle breakdown called rhabdomyolysis within hours—you feel sharp pain, stiffness, and weakness with dark urine as muscle enzymes climb over 10,000 units per liter, risking kidney damage if ignored, hitting fast in 6 to 12 hours and needing urgent help.

Liver overload at 500 milligrams or more shows up in a day with nausea, yellow skin, and right-side pain as enzymes exceed 200 units per liter—it heads toward failure without care. Gut trouble like vomiting, diarrhea, and cramps affects 10 to 20 percent at 300 milligrams or higher, lasting 12 to 24 hours and drying you out at 800 milligrams, signaling excess clearly.

Rare low blood pressure below 90/60 millimeters of mercury or confusion at 1000 milligrams suggests brain or vessel strain—it builds over hours to days, requiring a quick response to avoid collapse.

First Aid Measures

Stop Zocor immediately if you overdose and call for medical help right away—if it’s within 1 to 2 hours, like 400 milligrams, charcoal at 50 grams can grab it, and hospitals might wash your stomach to cut what gets in, all under professional watch.

Lie flat and sip 500 milliliters of water if you’re awake—IV saline, 1 liter in an hour, fights dehydration or low pressure below 90 millimeters of mercury, checked by pulse and pee flow over 30 milliliters per hour.

Muscle trouble with enzymes over 5000 units per liter needs IV fluids, 2 to 3 liters daily, and sodium bicarbonate at 100 milliequivalents to shield your kidneys—test every 6 hours until it’s under 1000 units per liter. Liver jumps with ALT over 200 units per liter rely on support—don’t self-fix—recovery needs lab checks to monitor kidney and liver health afterward.

Drug Interactions

Effects Other Medications

Simvastatin interacts with many drugs in complex ways—strong blockers like ketoconazole or itraconazole boost levels 10 to 20 times, raising muscle breakdown risks with creatine kinase over 10,000 units per liter. Zocor drops to 10 milligrams or switches to pravastatin—wait 14 days after blockers and check monthly with enzymes under 150 units per liter and lipids.

Fibrates like gemfibrozil triple muscle trouble odds, 5 percent versus 0.1 percent, at 40 to 80 milligrams—keep it at 10 milligrams and test enzymes weekly under 500 units per liter to avoid collapse. Amiodarone or verapamil, milder blockers, double levels at 80 milligrams—cap Zocor at 20 milligrams with biweekly lipids under 100 milligrams per deciliter and ECGs showing PR under 0.24 seconds to dodge issues.

Warfarin’s INR climbs 20-30 percent with Zocor—cut it 10-20 percent and check weekly INR at 2 to 3 to keep bleeding safe, ensuring a smooth fit with other treatments.

Compatibility Alcohol Food

Alcohol at 1 or 2 drinks lifts triglycerides 10 to 20 percent, slightly nudging Zocor’s work—stick to 1 daily and test lipids monthly, keeping triglycerides under 150 milligrams per deciliter to spot changes—over 4 drinks stress your liver, ALT over 40 units per liter, so cut back.

Fatty meals lift uptake 20-30 percent—take it after dinner—but grapefruit juice doubles it, so skip that. Weekly lipids catch rises, LDL-C over 100 milligrams per deciliter—keeps cuts steady—spicy or caffeine foods don’t affect it, so eat freely, but daily timing locks in Zocor’s effect.

Special Precautions

Use During Pregnancy and Breastfeeding

Zocor falls into pregnancy category X, meaning you can’t take it while pregnant since lowering cholesterol might harm a baby’s brain and spine development—studies suggest a defect risk up to 20 percent higher. If you could get pregnant, use reliable birth control or manage cholesterol with diet changes instead.

Your obstetrician will track lipid levels without statins—safer methods work through all three trimesters. Breastfeeding isn’t safe either—simvastatin slips into milk at 0.1 to 0.2 milligrams per liter from a 40-milligram dose, possibly affecting a baby’s cholesterol balance.

Watch for sleepiness or weak feeding in the infant—monthly doctor visits catch trouble early—safer options like bile acid binders step in if you need control while nursing.

Impact Driving Operating Machinery

Zocor might make you tired or achy in the first 2 to 4 weeks—higher doses like 80 milligrams could slow you more, affecting driving or machine use if you feel off.

Try it for a week or two—skip these tasks if soreness or fatigue persists—most feel fine by 4 weeks—recheck if your dose increases to keep risks low.

Considerations Elderly Pediatric Patients

Older adults start Zocor at 10 to 20 milligrams—slower livers stretch half-life to 4 or 5 hours—moving to 40 if LDL-C exceeds 100 milligrams per deciliter after 6 weeks. Check lipids every 3 months—under 70 milligrams per deciliter for high-risk—and enzymes under 150 units per liter catch soreness—fits frail bodies or drugs like amiodarone.

Kids 10 to 17 with family cholesterol issues use 10 to 40 milligrams—max 40 nightly—specialists watch lipids every 3 months—under 10 skips—diet fits growing kids safely.