The warfarin in Coumadin slows blood clotting, preventing blood clots. The drug is useful for arrhythmias, after heart surgery, or at risk of blood vessel blockage. Its action helps to keep blood flow normal, reducing the chance of dangerous clots. It is suitable for those who face clotting problems.
no RX
Dosage | Package | Per Item | Per Pack | Order |
5 mg |
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The pharmaceutical product is marketed under the trade name Coumadin, a widely recognized label within the medical field. This designation distinguishes it among anticoagulant therapies, offering a trusted option for managing specific health conditions.
Coumadin is identified globally by its international non-proprietary name, warfarin. This term refers to the active compound that drives its therapeutic effects, ensuring uniformity in its identification across different regions and healthcare systems.
This medication is primarily available in tablet form, designed for oral administration. The tablets come in various strengths, including 1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, and 10 mg, each distinguishable by color coding to facilitate accurate dosing and patient compliance.
The core active ingredient in Coumadin is warfarin sodium, a derivative of coumarin that exerts its anticoagulant properties. Accompanying this are inactive substances such as anhydrous lactose, magnesium stearate, cornstarch, and hydroxypropyl cellulose, which contribute to the tablet’s structure and stability. Certain formulations may include dyes like FD&C Blue No. 2 or FD&C Yellow No. 6 to differentiate strengths visually, ensuring safe and precise use.
Coumadin operates by interfering with the body’s ability to synthesize functional clotting factors dependent on vitamin K. It inhibits the enzyme vitamin K epoxide reductase, which disrupts the recycling of vitamin K, a crucial cofactor in the production of factors II, VII, IX, and X, as well as proteins C and S. This inhibition leads to a reduction in blood coagulability, extending the time required for clot formation. As a result, it effectively prevents the development and progression of thrombi, making it a vital tool in conditions prone to excessive clotting.
Upon ingestion, warfarin in Coumadin is absorbed rapidly and almost completely from the gastrointestinal tract, with peak plasma concentrations occurring within 4 hours. It binds extensively to plasma proteins, predominantly albumin, at approximately 99%, which limits its free fraction in circulation. Metabolism takes place in the liver, mediated by cytochrome P450 enzymes, notably CYP2C9, CYP1A2, and CYP3A4, producing several hydroxylated metabolites with minimal activity. Excretion occurs mainly via urine as these metabolites, with a small amount eliminated in bile. The half-life of warfarin varies widely, averaging 20 to 60 hours, influenced by genetic factors, age, and concurrent medications.
Coumadin is indicated for the prevention and treatment of thromboembolism in various clinical scenarios. It is commonly prescribed for patients with atrial fibrillation to reduce the risk of stroke caused by clot formation in the heart. The medication also plays a key role in managing deep vein thrombosis and pulmonary embolism, either as a preventative measure or following an acute event. Additionally, it is used in individuals with mechanical heart valves or those recovering from certain orthopedic surgeries, such as hip or knee replacements, where immobility heightens clotting risk.
Coumadin must not be administered to patients with a confirmed allergy to warfarin or any excipient in its formulation, as reactions could range from skin irritation to severe immune responses. It is unsuitable for individuals with active bleeding or a history of hemorrhagic tendencies, such as hemophilia or gastrointestinal ulcers, due to the potential for exacerbating blood loss. Use is also precluded in cases of recent or impending surgery involving the central nervous system, eyes, or spine, where bleeding risks are particularly high. Severe uncontrolled hypertension and bacterial endocarditis further prohibit its application, as does advanced liver disease or significant thrombocytopenia, which impair clotting regulation and heighten complication risks.
Coumadin tablets are taken orally, typically once daily at the same time to maintain consistent blood levels. They can be consumed with or without food, as dietary intake does not significantly alter absorption. Patients should swallow the tablet whole with a glass of water, avoiding splitting or crushing unless directed by a healthcare provider. Regular monitoring of the International Normalized Ratio (INR) is essential to ensure therapeutic efficacy and safety.
For adults, Coumadin dosing begins with an initial range of 2 to 5 mg daily, adjusted based on INR results targeting a therapeutic range of 2.0 to 3.0 for most indications, or 2.5 to 3.5 for mechanical valves. Maintenance doses vary widely, often settling between 2 and 10 mg daily, tailored to individual response. In children, use is less common and requires specialist oversight; dosing typically starts at 0.2 mg/kg once daily, capped at 10 mg, with adjustments guided by INR and clinical need, reflecting limited pediatric data.
Renal impairment does not necessitate routine dose changes, as warfarin is metabolized hepatically, though cautious monitoring is advised in severe cases due to potential protein-binding alterations. In hepatic dysfunction, particularly moderate to severe, lower doses are critical, as impaired liver function slows metabolism and increases bleeding risk; use may be contraindicated in advanced stages. Elderly patients often require reduced starting doses, such as 2 mg, due to slower clearance and heightened sensitivity, with frequent INR checks to fine-tune therapy.
Coumadin can elicit various unintended effects, with bleeding being the most prominent concern. Minor bleeding may manifest as nosebleeds, gum sensitivity, or easy bruising, while severe cases could involve gastrointestinal hemorrhage or intracranial bleeding. Skin reactions, including rashes or, rarely, necrosis, have been noted, particularly early in therapy. Other effects include nausea, abdominal discomfort, or mild hair loss, which typically resolve over time. Fatigue, fever, or taste changes occasionally occur, and prolonged use may lead to osteoporosis due to vitamin K interference. Patients experiencing persistent or alarming symptoms should seek medical evaluation promptly.
An overdose of Coumadin can result in excessive anticoagulation, leading to widespread bleeding signs such as prolonged nosebleeds, blood in urine or stool, or unusual bruising. Severe cases might present with internal hemorrhage, causing symptoms like severe headache, confusion, or abdominal pain. Hypotension or shock could develop if blood loss is significant, while prolonged INR elevation confirms the extent of overdose, necessitating immediate action.
In response to a Coumadin overdose, cessation of the drug is the first step, followed by urgent medical contact. Vitamin K (phytonadione) administration, typically 5-10 mg intravenously, serves as an antidote to reverse anticoagulation, with effects starting within hours. For active bleeding, fresh frozen plasma or prothrombin complex concentrate may be infused to rapidly restore clotting factors. Monitoring INR and vital signs guides ongoing care, while avoiding further warfarin until stabilized is critical to recovery.
Coumadin interacts extensively with other drugs, primarily through its metabolism via CYP450 enzymes. Inhibitors like fluconazole, amiodarone, or metronidazole can increase warfarin levels, amplifying bleeding risk, while inducers such as carbamazepine, rifampin, or phenobarbital decrease its effectiveness, requiring dose adjustments. It may enhance the effects of other anticoagulants or antiplatelet agents, necessitating careful INR monitoring. Drugs affecting vitamin K, like broad-spectrum antibiotics, can also alter its action, demanding close supervision to maintain therapeutic balance.
Moderate alcohol use may heighten Coumadin’s anticoagulant effect, increasing bleeding tendencies, and should be limited. Foods rich in vitamin K, such as leafy greens, broccoli, or liver, can counteract its efficacy if consumed inconsistently; patients are encouraged to maintain steady dietary habits rather than eliminate these foods entirely. Cranberry products and certain herbal supplements, like ginkgo or garlic, may also potentiate its effects, warranting caution and consultation with healthcare providers.
Coumadin is contraindicated in pregnancy, particularly in the first trimester, due to its teratogenic potential, which includes risks of fetal hemorrhage and congenital malformations like nasal hypoplasia or stippled epiphyses. It should only be considered in exceptional cases, such as with mechanical valves, under strict specialist guidance with alternatives like heparin preferred. Warfarin passes into breast milk in trace amounts, but breastfeeding is generally deemed safe, as no significant effects on infants have been documented; monitoring remains prudent.
Coumadin itself does not typically impair cognitive or motor skills, but bleeding-related complications, such as dizziness or weakness from blood loss, could affect driving or machinery use. Patients should avoid these activities if they experience such symptoms, particularly during dose adjustments or if bleeding signs emerge, ensuring safety until stabilized.
Elderly patients often exhibit greater sensitivity to Coumadin, with slower metabolism and higher bleeding risk, necessitating lower initial doses and meticulous INR monitoring. In children, its use is rare and reserved for specific conditions like congenital heart defects, with dosing individualized based on weight and response, under expert care due to limited experience and variable pharmacokinetics. Both groups benefit from tailored management to balance efficacy and safety effectively.