The second-generation cephalosporin in Cefaclor is used for bacterial infections. The drug helps in otitis media, pharyngitis, urinary tract and skin infections. It has activity against Gram-positive and some Gram-negative bacteria. It is recommended for patients with mild to moderate infections, the dosage depends on age and severity of the condition. Used for symptomatic relief.
no RX
Dosage | Package | Per Item | Per Pack | Order |
250 mg |
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500 mg |
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The drug is presented on the market under the trade name Cefaclor. This name is used to designate the drug in the pharmacy network and medical practice.
The international nonproprietary name of the medicine is cefaclor. It indicates the active component underlying the therapeutic effect.
The drug is available in different forms, which allows you to take into account the age of the patient and the peculiarities of treatment:
The choice of form depends on the clinical situation and the physician's preference.
The main active substance is cefaclor, a second-generation antibiotic from the group of cephalosporins. Auxiliary components in capsules include:
Sweeteners (sucrose), flavorings (e.g., strawberry), xanthan gum for density are added to the suspension. The composition may vary slightly depending on the manufacturer.
The drug has a bactericidal action, disrupting the synthesis of peptidoglycan in the cell wall of bacteria. This is achieved by inhibiting transpeptidases, which leads to lysis of microorganisms. It is active against Gram-positive bacteria (Streptococcus pyogenes, Staphylococcus aureus, including penicillinase-producing strains) and Gram-negative microorganisms (Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae). Resistance to beta-lactamases is moderate, making it effective in a number of cases where first-generation drugs are powerless.
Action begins rapidly when the therapeutic concentration is reached in the focus of infection.
After oral administration, the active substance is absorbed in the small intestine, reaching peak blood concentrations in 0.5-1 hour. Bioavailability is about 90% when taken on an empty stomach, but decreases by 25-30% when taken with food.
The compound is distributed in tissues including lungs, skin, bone, and urinary tract. Binding to plasma proteins is low - about 25%, which contributes to good penetration into foci of inflammation.
Metabolism is minimal, most of the substance remains unchanged. A small proportion is converted into inactive metabolites in the liver.
It is excreted mainly by the kidneys (70-80% unchanged) through tubular filtration and tubule secretion. The elimination half-life is about 0.6-1 hour in patients with normal renal function.
The drug is used for the treatment of infectious diseases caused by sensitive pathogens:
Prescription requires bacteriologic confirmation in complicated cases.
The use is prohibited in:
With caution, use in colitis or blood coagulation disorders.
Capsules or suspension is taken orally, drinking water (100-150 ml). It is better to take on an empty stomach 1 hour before a meal or 2 hours after for maximum absorption. The suspension is prepared by adding water up to the mark, shake before each administration.
Dosage depends on the severity of the infection:
In renal insufficiency:
Hepatic insufficiency does not require correction.
Unwanted reactions may include:
Treatment should be discontinued for serious symptoms.
Exceeding the dose is manifested by nausea, vomiting, convulsions, confusion.
In overdose:
The medication may:
Alcohol does not affect directly, but may worsen the condition in infection. Food decreases the rate of absorption.
The use in pregnancy is allowed under strict indications (category B). Penetrates into milk, it is recommended to suspend lactation.
Faintness or dizziness may affect the ability to drive machinery.
The elderly require monitoring of renal function. In children the drug is safe from 1 month of age with accurate dosage.